1-Butanesulfonyl chloride → HCID 25234239, compound

Participants

Reaction Steps

To a stirred solution of isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine (example 15, step 2, 56 mg) in dichloromethane (1 mL) were added dimethylketene methyltrimethylsilylacetal (60 mg) and 1-butanesulfonyl chloride (41 mg). The mixture was stirred for 2 days at r.t. The mixture was diluted with dichloromethane and washed with water. The organic phase was dried (MgSO4), filtered and concentrated under reduced pressure. The product was purified by chromatography (SiO2, cyclohexane/ethyl acetate 9:1 to 1:1) to give butane-1-sulfonic acid isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amide as a colorless solid. MS: 461.4 ([M+NH4]+)

Provenance & Evidence