Cesium carbonate → HCID 25234252, compound

Participants

Reaction Steps

In analogy to example 10, step 3, N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-2-trifluoromethyl-benzenesulfonamide (example 27, step 1) was reacted with N,N-diethylchloro acetamide and cesium carbonate in N,N-dimethylacetamide for 1 day at r.t., for 18 h at 50° C. and for 6 h at 100° C. to give N,N-diethyl-2-[[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-(2-trifluoromethyl-benzenesulfonyl)-amino]-acetamide as a light yellow oil. MS: 588.8 ([M+NH4]+)

Provenance & Evidence