HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → N-(4-bromo-2-fluoro-benzyl)-2-chloro-N-isobutyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Bromo-2-fluorobenzyl bromide | HCID 2733660 | — |
| Reactant | 2-chloro-N-isobutyl-benzenesulfonamide | HCID 8469376 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | N-(4-bromo-2-fluoro-benzyl)-2-chloro-N-isobutyl-benzenesulfonamide | HCID 67441654 | — |
Reaction Steps
In analogy to example 10, step 3, 2-chloro-N-isobutyl-benzenesulfonamide was reacted with 4-bromo-2-fluorobenzyl bromide, cesium carbonate and 10 mol-% tetrabutylammonium iodide as a catalyst in N,N-dimethylacetamide to give N-(4-bromo-2-fluoro-benzyl)-2-chloro-N-isobutyl-benzenesulfonamide as a colorless oil. MS: 434.2 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039493B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-eb985f803651430dad7fe50da4103203 |
| Source note | uspto-grants-2011_10 |