HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → N-(5-bromo-pyridin-3-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-chloro-N-isobutyl-benzenesulfonamide | HCID 8469376 | — |
| Reactant | 3-Bromo-5-(chloromethyl)pyridine hydrochloride | HCID 12515069 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | N-(5-bromo-pyridin-3-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide | HCID 67440142 | — |
Reaction Steps
In analogy to example 10, step 3, 2-chloro-N-isobutyl-benzenesulfonamide (example 42, step 1) was reacted with 3-bromo-5-(chloromethyl)pyridine hydrochloride and cesium carbonate in N,N-dimethylacetamide to give N-(5-bromo-pyridin-3-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide as a colorless oil. MS: 417.2 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039493B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-a6545a0e15c24c7680ab0b948b331cdc |
| Source note | uspto-grants-2011_10 |