HRID1665071

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

HCID2773542

3-(Methylsulfonyl)phenylboronic acid

C7H9BO4S

结构：CC(C)CN(Cc1cccc(Br)n1)S(=O)(=O)c1ccccc1Cl

HCID86629145

未命名化合物

PRODUCTS

生成物

结构：CC(C)CN(Cc1cccc(-c2cccc(S(C)(=O)=O)c2)n1)S(=O)(=O)c1ccccc1Cl

HCID25234314

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：ClCCl.Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1

催化剂HCID178418807

未命名化合物

溶剂HCID21886435

1,4-Dioxane--water (1/1)

C4H10O3

PROCEDURE

实验过程

In analogy to example 1, step 3, N-(6-bromo-pyridin-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide was reacted with (3-methylsulfonylphenyl)-boronic acid, Na2CO3 and dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct in dioxane/water to give 2-chloro-N-isobutyl-N-[6-(3-methanesulfonyl-phenyl)-pyridin-2-ylmethyl]-benzenesulfonamide as a colorless solid. MS: 492.9 ([M+H]+)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-336c228d175447dfbdc72898a00b7616
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08039493B2
来源说明: uspto-grants-2011_10

反应 SMILES

Br[C:2]1[N:7]=[C:6]([CH2:8][N:9]([CH2:20][CH:21]([CH3:23])[CH3:22])[S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])(=[O:12])=[O:11])[CH:5]=[CH:4][CH:3]=1.[CH3:24][S:25]([C:28]1[CH:29]=[C:30](B(O)O)[CH:31]=[CH:32][CH:33]=1)(=[O:27])=[O:26].C([O-])([O-])=O.[Na+].[Na+]>O1CCOCC1.O.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].ClCCl>[Cl:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[S:10]([N:9]([CH2:20][CH:21]([CH3:23])[CH3:22])[CH2:8][C:6]1[CH:5]=[CH:4][CH:3]=[C:2]([C:32]2[CH:31]=[CH:30][CH:29]=[C:28]([S:25]([CH3:24])(=[O:27])=[O:26])[CH:33]=2)[N:7]=1)(=[O:12])=[O:11]