HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → N-(2-bromo-pyridin-4-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | 2-chloro-N-isobutyl-benzenesulfonamide | HCID 8469376 | — |
| Reactant | (2-Bromopyridin-4-yl)methanol | HCID 14512957 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(2-bromo-pyridin-4-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide | HCID 86629146 | — |
Reaction Steps
In analogy to example 45, step 1, 2-chloro-N-isobutyl-benzenesulfonamide (example 42, step 1) was reacted with (2-bromo-pyridin-4-yl)-methanol (CAS [118289-16-0]), triphenylphosphine and diethyl azodicarboxylate in tetrahydrofuran to give N-(2-bromo-pyridin-4-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide as a colorless oil. MS: 417.2 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039493B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-d971fedbdf8840f98404fa725886d035 |
| Source note | uspto-grants-2011_10 |