Sodium Carbonate → HCID 67438422, compound

HRID 1665075Notes

Reaction equation

HRID 1665075 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[CH2:5][NH:6][S:7]([CH:10]([CH3:12])[CH3:11])(=[O:9])=[O:8].[CH3:16][S:17]([C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[CH:24][CH:25]=1)(=[O:19])=[O:18].C([O-])([O-])=O.[Na+].[Na+]>O1CCOCC1.O.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].ClCCl>[CH3:16][S:17]([C:20]1[CH:25]=[C:24]([C:2]2[CH:15]=[CH:14][CH:13]=[C:4]([CH2:5][NH:6][S:7]([CH:10]([CH3:12])[CH3:11])(=[O:9])=[O:8])[CH:3]=2)[CH:23]=[CH:22][CH:21]=1)(=[O:19])=[O:18]

Participants

6

Reactant 3

HCID 10340Sodium CarbonateHCID 27735423-(Methylsulfonyl)phenylboronic acidHCID 61410043HCID 61410043, compound

Product 1

HCID 67438422HCID 67438422, compound

Reagents, catalysts & solvents 2

HCID 178418807HCID 178418807, compoundCatalystHCID 218864351,4-Dioxane--water (1/1)Solvent

Procedure

In analogy to example 1, step 3, propane-2-sulfonic acid 3-bromo-benzylamide was reacted with (3-methylsulfonylphenyl)-boronic acid, Na2CO3 and dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct in dioxane/water to give propane-2-sulfonic acid (3′-methanesulfonyl-biphenyl-3-ylmethyl)-amide as an off-white solid.

Sources & evidence

ORD record
ord-570ac3c778fa40f48fa4f3cf3f870052
Source dataset
uspto-grants-2011_10
Patent number
US08039493B2

Reaction notes

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