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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1665079Generated: October 30, 2026

Cesium carbonate → HCID 25234319, compound

https://huagongshe.com/reaction/1665079

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCesium carbonateHCID 10796—
Reactantalpha-Bromo-o-fluorotolueneHCID 67968—
ReactantHCID 67438422HCID 67438422—
CatalystTetrabutylammonium IodideHCID 67553—
SolventDimethylacetamideHCID 31374—
ProductHCID 25234319HCID 25234319—

Reaction Steps

In analogy to example 10, step 3, propane-2-sulfonic acid (3′-methanesulfonyl-biphenyl-3-ylmethyl)-amide (example 49, step 2) was reacted with 2-fluorobenzyl bromide, tetrabutylammonium iodide and cesium carbonate in N,N-dimethylacetamide to give propane-2-sulfonic acid (2-fluoro-benzyl)-(3′-methanesulfonyl-biphenyl-3-ylmethyl)-amide as a colorless solid. MS: 476.4 ([M+H]+)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08039493B2
Source datasetuspto-grants-2011_10
ORD IDord-9448681fd2cf498287aa5a728ac285ec
Source noteuspto-grants-2011_10