HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 25234319, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | alpha-Bromo-o-fluorotoluene | HCID 67968 | — |
| Reactant | HCID 67438422 | HCID 67438422 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 25234319 | HCID 25234319 | — |
Reaction Steps
In analogy to example 10, step 3, propane-2-sulfonic acid (3′-methanesulfonyl-biphenyl-3-ylmethyl)-amide (example 49, step 2) was reacted with 2-fluorobenzyl bromide, tetrabutylammonium iodide and cesium carbonate in N,N-dimethylacetamide to give propane-2-sulfonic acid (2-fluoro-benzyl)-(3′-methanesulfonyl-biphenyl-3-ylmethyl)-amide as a colorless solid. MS: 476.4 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039493B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-9448681fd2cf498287aa5a728ac285ec |
| Source note | uspto-grants-2011_10 |