Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 2-chloro-N-isobutyl-N-[4-(3-tert-butylaminosulfonyl-phenyl)-thiophen-2-ylmethyl]-benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 3-(tert-Butylaminosulphonyl)benzeneboronic acid | HCID 44119538 | — |
| 반응물 | N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide | HCID 67439155 | — |
| 촉매 | HCID 178418807 | HCID 178418807 | — |
| 용매 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 생성물 | 2-chloro-N-isobutyl-N-[4-(3-tert-butylaminosulfonyl-phenyl)-thiophen-2-ylmethyl]-benzenesulfonamide | HCID 25234323 | — |
반응 단계
In analogy to example 1, step 3, N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide (example 14, step 2) was reacted with 3-tert-butylsulfamoyl-benzeneboronic acid (CAS [221290-14-8]), Na2CO3 and dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct in dioxane/water to give 2-chloro-N-isobutyl-N-[4-(3-tert-butylaminosulfonyl-phenyl)-thiophen-2-ylmethyl]-benzenesulfonamide as an off-white solid. MS: 553.6 ([M−H]−)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08039493B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-5de21a3ed28247ac8a2788d5ef48e02d |
| 출처 메모 | uspto-grants-2011_10 |