HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylmethanesulfonyl chloride → HCID 25234324, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylmethanesulfonyl chloride | HCID 74740 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine | HCID 67441398 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 25234324 | HCID 25234324 | — |
Reaction Steps
In analogy to example 13, step 2, isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine (example 15, step 2) was reacted with alpha-toluenesulfonyl chloride and N,N-diisopropyl ethyl amine in dichloromethane to give N-isobutyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-C-phenyl-methanesulfonamide as an off-white solid. MS: 495.2 ([M+NH4]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039493B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-aa8c45799fa6461daadaef88e41296ab |
| Source note | uspto-grants-2011_10 |