Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-amino-1-benzylpiperidine-4-carbonitrile | HCID 10680206 | — |
| Reactant | 3,5-Diamino-6-chloro-N-[(methylsulfanyl)methanimidoyl]pyrazine-2-carboxamide | HCID 140444318 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 178508761 | HCID 178508761 | — |
Reaction Steps
4-Amino-1-benzyl-piperidine-4-carbonitrile (Intermediate G) (200 mg, 0.91 mmol) in dry propan-2-ol (10 ml) is treated with triethylamine (0.25 ml) followed by 1-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-2-methyl-isothiourea (Intermediate A) (355 mg, 0.91 mmol). The mixture is heated at 70° C. for 5 hours and then allowed to cool to room temperature. The precipitate is collected and washed with methanol to afford the title compound as a light yellow solid, 190 mg; [M+H]+ 415
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08039472B2 |
|---|
| Source dataset | uspto-grants-2011_10 |
|---|
| ORD ID | ord-29f847d2e02544298b211ce2abb87b9a |
|---|
| Source note | uspto-grants-2011_10 |
|---|
