HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 5-Oxo-1-(3-pyrrol-1-yl-propyl)-pyrrolidine-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(3-Bromopropyl)pyrrole | HCID 557119 | — |
| Reactant | 5-Oxo-pyrrolidine-3-carboxylic acid methyl ester | HCID 13118117 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Oxo-1-(3-pyrrol-1-yl-propyl)-pyrrolidine-3-carboxylic acid methyl ester | HCID 67120716 | — |
Reaction Steps
To a solution of 5-Oxo-pyrrolidine-3-carboxylic acid methyl ester (1 eq.) in dry DMF is added NaH (1.1 eq.) followed by 1-(3-bromo-propyl)-1H-pyrrole (1 eq.). The reaction mixture is stirred at room temperature overnight. Purification is by normal phase chromatography to yield 5-Oxo-1-(3-pyrrol-1-yl-propyl)-pyrrolidine-3-carboxylic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039472B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-2be75b6685914863b5c42917186c9249 |
| Source note | uspto-grants-2011_10 |