Sodium Hydroxide → HCID 67086703, compound

HRID 1665166Notes

Reaction equation

HRID 1665166 reaction equation
C[O:2][C:3](=[O:18])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:7][CH:6]=1.[OH-].[Na+]>CO>[CH3:17][O:16][CH2:15][CH2:14][O:13][CH2:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([CH2:4][C:3]([OH:18])=[O:2])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11470803HCID 11470803, compound

Product 1

HCID 67086703HCID 67086703, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of [4-(2-Methoxy-ethoxymethoxy)-phenyl]-acetic acid methyl ester (192 mg, 0.76 mmol) in MeOH (3 ml) is added 2 M NaOH (3 ml). The reaction mixture is stirred for 16 hours at room temperature. The solvent is removed in vacuo and the residue dissolved in EtOAc and washed with sat. aq. NH4C1 solution, dried (MgSO4) and concentrated in vacuo to yield [4-(2-Methoxy-ethoxymethoxy)-phenyl]-acetic acid

Workup

  1. customThe solvent is removed in vacuo
  2. dissolutionthe residue dissolved in EtOAc
  3. washwashed with sat. aq. NH4C1 solution
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-48350e6972414775a9ee21008e72e471
Source dataset
uspto-grants-2011_10
Patent number
US08039472B2

Reaction notes

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