2-(2-Bromoethoxy)tetrahydro-2H-pyran → HCID 67086830, compound

HRID 1665179Notes

Reaction equation

HRID 1665179 reaction equation
Br[CH2:2][CH2:3][O:4][CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][O:6]1.N1C2C=CC=C(C(OC)=O)C=2C=C1.[CH3:24][C:25]1[NH:26][C:27]2[C:32]([C:33]=1[CH3:34])=[CH:31][C:30]([C:35]([O-:37])=[O:36])=[CH:29][CH:28]=2>>[CH3:24][C:25]1[N:26]([CH2:2][CH2:3][O:4][CH:5]2[CH2:10][CH2:9][CH2:8][CH2:7][O:6]2)[C:27]2[C:32]([C:33]=1[CH3:34])=[CH:31][C:30]([C:35]([OH:37])=[O:36])=[CH:29][CH:28]=2

Participants

4

Reactant 3

HCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyranHCID 2733668methyl 1H-indole-4-carboxylateHCID 4062961HCID 4062961, compound

Product 1

HCID 67086830HCID 67086830, compound

Procedure

This compound is prepared analogously to Intermediate AO replacing (2-bromoethoxy)benzene with (2-(2-bromoethoxy)tetrahydro-2H-pyran and replacing Methyl indole-4-carboxylate with 2,3-dimethyl-1H-indole-5-carboxylate; [M+H]+ 318

Workup

  1. customThis compound is prepared analogously to Intermediate AO

Sources & evidence

ORD record
ord-52f6506471c74abda833444b3754a1da
Source dataset
uspto-grants-2011_10
Patent number
US08039472B2

Reaction notes

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