HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-amino-4-cyanopiperidine-1-carboxylate → 4-(Aminomethyl)-1-(1-phenylethyl)piperidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-amino-4-cyanopiperidine-1-carboxylate | HCID 22091429 | — |
| Reactant | tert-Butyl 4-amino-4-(aminomethyl)piperidine-1-carboxylate | HCID 22975818 | — |
| Reactant | 4-Amino-1-(1-phenyl-ethyl)-piperidine-4-carbonitrile | HCID 67120708 | — |
| Product | 4-(Aminomethyl)-1-(1-phenylethyl)piperidin-4-amine | HCID 67086870 | — |
Reaction Steps
4-Aminomethyl-1-(1-phenyl-ethyl)-piperidin-4-ylamine is prepared analogously to Intermediate U by replacing 4-amino-4-cyano-piperidine-1-carboxylic acid tert-butyl ester in Step 1 with 4-amino-1-(1-phenyl-ethyl)-piperidine-4-carbonitrile; [M+H]+ 234.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039472B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-a1503759a9fa4718bcbd6742a5e98251 |
| Source note | uspto-grants-2011_10 |