p-Toluenesulfonic acid → HCID 86634960, compound

Participants

Reaction Steps

Under nitrogen atmosphere, a mixture of 0.46 g of t-butyl (1R)-trans-2,2-dimethyl-3-[(E)-2-methyl-3-(2-propynyloxyimino)-1-propenyl]cyclopropanecarboxylate, catalytic amount of p-toluenesulfonic acid and 10 ml of toluene was stirred for 3.5 hours under reflux. The reaction mixture was cooled down to room temperature, then, the mixture was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.35 g of (1R)-trans-2,2-dimethyl-3-[(E)-2-methyl-3-(2-propynyloxyimino)-1-propenyl]cyclopropanecarboxylic acid:

Provenance & Evidence