Hydrochloric Acid → HCID 28831601, compound

Participants

Reaction Steps

A solution of 3-(4-bromo-2-fluoro-phenoxymethyl)-benzoic acid methyl ester (5.5 g, 16.22 mmol) in dioxane was treated with a solution of lithium hydroxide (1.86 g, 81.1 mmol) in water at room temperature overnight, followed by acidification with concentrated HCl and diluted with water. The precipitate was collected by filtration, washed with water, and dried to give 3-(4-bromo-2-fluoro-phenoxymethyl)-benzoic acid, 5.2 g (99%). LC-MS (ES) calculated for C14H10BrFO3, 323; found m/z 324 [M+H]+.

Provenance & Evidence