3,5-Dimethylisoxazole-4-carbonyl Chloride → HCID 57661882, compound

HRID 1665276Notes

Reaction equation

HRID 1665276 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.[CH3:22][C:23]1[C:27]([C:28](Cl)=[O:29])=[C:26]([CH3:31])[O:25][N:24]=1>>[CH3:22][C:23]1[C:27]([C:28]([N:1]2[CH2:2][CH2:3][C:4]3([O:11][C:10]4[C:12]5[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=4[S:8][CH2:7]3)=[CH:16][CH:15]=[CH:14][CH:13]=5)[CH2:5][CH2:6]2)=[O:29])=[C:26]([CH3:31])[O:25][N:24]=1

Participants

3

Reactant 2

HCID 27362653,5-Dimethylisoxazole-4-carbonyl ChlorideHCID 57661820Spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

Product 1

HCID 57661882HCID 57661882, compound

Procedure

Compound 40 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 3,5-dimethylisoxazole-4-carbonyl chloride and conditions outlined in procedure N. M.p.=274-275° C.; 300 MHz 1H NMR (DMSO-d6) δ 8.08 (d, 1H), 7.73 (m, 2H), 7.54 (t, 1H), 3.42 (t, 2H), 2.99 (s, 2H), 2.45 (s, 3H), 2.31 (s, 3H), 2.21 (m, 2H), 1.90 (brm 2H), 1.58 (s, 2H); LCMS: 425 [M+H].

Sources & evidence

ORD record
ord-3383ae47621f471e95f2d293223ef622
Source dataset
uspto-grants-2011_10
Patent number
US08039503B2

Reaction notes

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