2,5-Dimethyl-3-furoyl Chloride → HCID 57662052, compound

HRID 1665277Notes

Reaction equation

HRID 1665277 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.[CH3:22][C:23]1[O:24][C:25]([CH3:31])=[CH:26][C:27]=1[C:28](Cl)=[O:29]>>[CH3:22][C:23]1[O:24][C:25]([CH3:31])=[CH:26][C:27]=1[C:28]([N:1]1[CH2:2][CH2:3][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:5][CH2:6]1)=[O:29]

Participants

3

Reactant 2

HCID 27348042,5-Dimethyl-3-furoyl ChlorideHCID 57661820Spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

Product 1

HCID 57662052HCID 57662052, compound

Procedure

Compound 41 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 2,5-dimethyl-3-furoyl chloride and conditions outlined in procedure N. M.p.=234-235° C.; 300 MHz 1H NMR (DMSO-d6) δ 8.15 (d, 1H), 7.81 (d, 1H), 7.63 (t, 1H), 7.54 (t, 1H), 5.92 (s, 1H), 3.40 (m, 2H), 3.05 (s, 2H), 2.40 (s, 3H), 2.21 (s, 3H), 2.18 (m, 2H), 1.90 (m 2H), 1.60 (s, 2H); LCMS: 424 [M+H].

Sources & evidence

ORD record
ord-fbbba7bdf6f142898511ca49e1a27fab
Source dataset
uspto-grants-2011_10
Patent number
US08039503B2

Reaction notes

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