2,5-Dimethyl-2H-pyrazole-3-carbonyl chloride → HCID 57661939, compound

HRID 1665278Notes

Reaction equation

HRID 1665278 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.[CH3:22][N:23]1[C:27]([C:28](Cl)=[O:29])=[CH:26][C:25]([CH3:31])=[N:24]1>>[CH3:22][N:23]1[C:27]([C:28]([N:1]2[CH2:2][CH2:3][C:4]3([O:11][C:10]4[C:12]5[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=4[S:8][CH2:7]3)=[CH:16][CH:15]=[CH:14][CH:13]=5)[CH2:5][CH2:6]2)=[O:29])=[CH:26][C:25]([CH3:31])=[N:24]1

Participants

3

Reactant 2

HCID 27362992,5-Dimethyl-2H-pyrazole-3-carbonyl chlorideHCID 57661820Spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

Product 1

HCID 57661939HCID 57661939, compound

Procedure

Compound 42 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 1,3-dimethyl-1H-pyrazole-5-carbonyl chloride and conditions outlined in procedure N. M.p.=244-245° C.; 300 MHz 1H NMR (DMSO-d6) δ 8.07 (d, 1H), 7.67 (d, 1H), 7.65 (t, 1H), 7.56 (t, 1H), 6.16 (s, 1H), 3.40 (m, 2H), 3.86 (s, 3H), 3.01 (s, 2H), 2.26 (s, 3H), 2.24 (m, 2H), 1.92 (m, 2H), 1.62 (m, 2H); LCMS: 424 [M+H].

Sources & evidence

ORD record
ord-50e95c51048240d284ffcf0ae41f568c
Source dataset
uspto-grants-2011_10
Patent number
US08039503B2

Reaction notes

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