4-(1H-pyrazol-1-yl)benzoyl chloride → HCID 57662005, compound

HRID 1665280Notes

Reaction equation

HRID 1665280 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.[N:22]1([C:27]2[CH:35]=[CH:34][C:30]([C:31](Cl)=[O:32])=[CH:29][CH:28]=2)[CH:26]=[CH:25][CH:24]=[N:23]1>>[N:22]1([C:27]2[CH:35]=[CH:34][C:30]([C:31]([N:1]3[CH2:2][CH2:3][C:4]4([O:11][C:10]5[C:12]6[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=5[S:8][CH2:7]4)=[CH:16][CH:15]=[CH:14][CH:13]=6)[CH2:5][CH2:6]3)=[O:32])=[CH:29][CH:28]=2)[CH:26]=[CH:25][CH:24]=[N:23]1

Participants

3

Reactant 2

HCID 27764744-(1H-pyrazol-1-yl)benzoyl chlorideHCID 57661820Spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

Product 1

HCID 57662005HCID 57662005, compound

Procedure

Compound 44 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 4-(1H-pyrazol-1-yl)benzoyl chloride and conditions outlined in procedure N. M.p.=299-300° C.; 300 MHz 1H NMR (DMSO-d6) δ 8.06 (d, 1H), 8.0 (s, 1H), 7.64 (m, 4H), 7.65 (t, 1H), 7.50 (m, 3H), 6.52 (s, 1H), 3.42 (m, 2H), 2.96 (s, 2H), 2.22 (m, 2H), 1.92 (m 2H), 1.58 (s, 2H); LCMS: 472 [M+H].

Sources & evidence

ORD record
ord-3c4faadddbaa4468b74c5de8b9b3b607
Source dataset
uspto-grants-2011_10
Patent number
US08039503B2

Reaction notes

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