Benzoyl chloride, 3-chloro- → HCID 57661854, compound

HRID 1665301Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:25]=[C:24]3[C:10]([C:11](=[O:27])[C:12](=[O:26])[C:13]4[S:23][CH2:22][C:16]5([CH2:21][CH2:20][NH:19][CH2:18][CH2:17]5)[O:15][C:14]=43)=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.[Cl:28][C:29]1[CH:30]=[C:31]([CH:35]=[CH:36][CH:37]=1)[C:32](Cl)=[O:33]>>[Cl:28][C:29]1[CH:30]=[C:31]([CH:35]=[CH:36][CH:37]=1)[C:32]([N:19]1[CH2:20][CH2:21][C:16]2([O:15][C:14]3[C:24]4[C:10]([C:11](=[O:27])[C:12](=[O:26])[C:13]=3[S:23][CH2:22]2)=[CH:9][CH:8]=[C:7]([C:4]2[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=2)[CH:25]=4)[CH2:17][CH2:18]1)=[O:33]

Participants

Reactant 2

HCID 69252Benzoyl chloride, 3-chloro-

HCID 57661936HCID 57661936, compound

Product 1

HCID 57661854HCID 57661854, compoundYield 99%

Procedure

Compound 66 was synthesized using 9-pyridin-4-ylspiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 3-chlorobenzoyl chloride and conditions outlined in procedure N. Yield: 99%. Mp.: 265-267° C.; 400 MHz 1H NMR (DMSO-d6) δ 8.75 (m, 2H), 8.08 (d, J=1.6 Hz, 1H), 8.03 (d, J=8.4 Hz, 1H), 7.98 (dd, J=1.6, 8.0 Hz, 1H), 7.83 (m, 2H), 7.56-7.47 (m, 3H), 7.41 (dt, J=1.2, 7.6 Hz, 1H), 4.32 (br, 1H), 3.50 (br, 2H), 3.38-3.30 (m, 1H), 3.14 (s, 2H), 2.15 (m, 1H), 2.02 (m, 1H), 1.91 (m, 2H); LCMS: 517 [M+H].

Sources & evidence

ORD record: ord-21a2773f3056484fb244980c7909a1cc
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08039503B2

Reaction notes

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