1-methyl-1H-imidazole-4-sulfonyl chloride → HCID 57662067, compound

HRID 1665311Notes

Reaction equation

HRID 1665311 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.[CH3:22][N:23]1[CH:27]=[C:26]([S:28](Cl)(=[O:30])=[O:29])[N:25]=[CH:24]1>>[CH3:22][N:23]1[CH:27]=[C:26]([S:28]([N:1]2[CH2:2][CH2:3][C:4]3([O:11][C:10]4[C:12]5[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=4[S:8][CH2:7]3)=[CH:16][CH:15]=[CH:14][CH:13]=5)[CH2:5][CH2:6]2)(=[O:30])=[O:29])[N:25]=[CH:24]1

Participants

3

Reactant 2

HCID 27368871-methyl-1H-imidazole-4-sulfonyl chlorideHCID 57661820Spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

Product 1

HCID 57662067HCID 57662067, compound

Procedure

Compound 79 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 1-methyl-1H-imidazole-4-sulfonyl chloride and conditions outlined in procedure P. M.p.=256-257° C.; 400 MHz 1H NMR (CDCl3) δ: 8.06-8.03 (m, 1H), 7.64-7.56 (m, 2H), 7.53-7.45 (m, 3H), 3.84-3.78 (m, 5H), 3.30-3.22 (m, 2H), 2.93 (s, 2H), 2.22-2.13 (m, 2H), 2.0-1.90 (m, 2H); LCMS: 446 [M+H].

Sources & evidence

ORD record
ord-41a4bf98f3094b17a1ad0a9332658a7a
Source dataset
uspto-grants-2011_10
Patent number
US08039503B2

Reaction notes

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