1-(Bromomethyl)-2,4-difluorobenzene → HCID 57662059, compound

HRID 1665323Notes

Reaction equation

HRID 1665323 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.Br[CH2:23][C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=1[F:31]>>[F:31][C:25]1[CH:26]=[C:27]([F:30])[CH:28]=[CH:29][C:24]=1[CH2:23][N:1]1[CH2:2][CH2:3][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 902971-(Bromomethyl)-2,4-difluorobenzeneHCID 57661820Spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

Product 1

HCID 57662059HCID 57662059, compound

Procedure

Compound 124 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 1-(bromomethyl)-2,4-difluorobenzene and conditions outlined in procedure V. M.p.=104-107° C.; 400 MHz 1H NMR (CDCl3) δ: 8.05 (d, 1H), 7.65 (m, 2H), 7.5 (t, 1H), 7.35 (q, 1H), 6.85 (m, 2H), 3.65 (s, 2H), 2.9 (s, 2H), 2.8 (d, 2H), 2.5 (t, 2H), 2.15 (d, 2H), 1.85 (t, 2H); LCMS: 428 [M+H].

Sources & evidence

ORD record
ord-07da5e4b0b4741a682a471f7156f610b
Source dataset
uspto-grants-2011_10
Patent number
US08039503B2

Reaction notes

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