Pentane, 3-(bromomethyl)- → HCID 57662026, compound

HRID 1665331Notes

Reaction equation

HRID 1665331 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.Br[CH2:23][CH:24]([CH2:27]C)[CH2:25][CH3:26]>>[CH3:23][CH:24]([CH3:27])[CH2:25][CH2:26][N:1]1[CH2:2][CH2:3][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 77432Pentane, 3-(bromomethyl)-HCID 57661820Spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

Product 1

HCID 57662026HCID 57662026, compound

Procedure

Compound 132 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 3-(bromomethyl)pentane and conditions outlined in procedure V. M.p.=143-146° C.; 400 MHz 1H NMR (DMSO-d6) δ: 7.9 (d, 1H), 7.75 (d, 2H), 7.55 (m, 1H), 3.05 (s, 2H), 2.7 (d, 2H), 2.35-2.2 (m, 4H), 1.95 (d, 2H), 1.8-1.7 (d, 2H), 1.6-1.5 (m, 1H), 1.35-1.25 (m, 2H), 0.9-0.8 (m, 6H); LCMS: 372 [M+H].

Sources & evidence

ORD record
ord-9aa2b6e387f14a2b8425468fbc687d1b
Source dataset
uspto-grants-2011_10
Patent number
US08039503B2

Reaction notes

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