4-(Bromomethyl)-2-chloro-1-fluorobenzene → HCID 23654793, compound

HRID 1665340Notes

Reaction equation

HRID 1665340 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.Br[CH2:23][C:24]1[CH:29]=[CH:28][C:27]([F:30])=[C:26]([Cl:31])[CH:25]=1>>[Cl:31][C:26]1[CH:25]=[C:24]([CH:29]=[CH:28][C:27]=1[F:30])[CH2:23][N:1]1[CH2:2][CH2:3][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 27575424-(Bromomethyl)-2-chloro-1-fluorobenzeneHCID 57661820Spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

Product 1

HCID 23654793HCID 23654793, compound

Procedure

Compound 142 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 4-(bromomethyl)-2-chloro-1-fluorobenzene and conditions outlined in procedure V. LCMS: 444 [M+H]; Rt=1.04 min.

Sources & evidence

ORD record
ord-ff4cc07670a84032b76615b8161a1504
Source dataset
uspto-grants-2011_10
Patent number
US08039503B2

Reaction notes

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