Benzene, (3-bromopropoxy)- → HCID 23654871, compound

Participants

Reaction Steps

Compound 144 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, bromo-3-phenoxypropane and conditions outlined in procedure W. M.p.=127-129° C.; 400 MHz 1H NMR (DMSO-d6) δ: 7.89 (d, J=7.6 Hz, 1H), 7.81-7.78 (m, 2H), 7.57 (dddd, J=2.4, 2.6, 5.2, 5.6 Hz, 2H), 7.28 (dd, J=6.8, 7.6 Hz, 2H), 6.94-6.86 (m, 4H), 4.01 (t, J=6.4 Hz, 2H), 3.08 (s, 2H), 2.77 (d, J=12.0 Hz, 2H), 2.55-2.47 (m, 2H), 2.34 (t, J=10.4 Hz, 2H), 2.00 (d, J=12.6 Hz, 2H), 1.903 (d, J=6.8 Hz, 2H), 1.81 (dt, J=4.0, 12.2 Hz, 2H); LCMS: 436 [M+H].

Provenance & Evidence