Water → HCID 67058885, compound

Participants

Reaction Steps

(S)-2-Bromo-N-methyl-N-(oxiran-2-ylmethyl)benzenesulfonamide (Exp. 1-1, 3.06 g) was dissolved in acetonitrile (25 mL), 2-methyl-1-(naphthalen-2-yl)propan-2-amine (am1, 1.99 g) and lithium perchlorate (KANTO, 1.06 g) were added thereto followed by reflux for 6 hours and 35 minutes. After cooling to room temperature, same amount of water and brine was added to the reaction solution and extraction was carried out with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography to obtain the target compound (3.97 g).

Provenance & Evidence