Hydrochloric Acid → HCID 67058926, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl (R)-3-(2′-(N-(2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propyl)-N-methylsulfamoyl)biphenyl-3-yl)acrylate synthesized from Example 3-1 Step A was dissolved in tetrahydrofuran (4 mL), water (1 mL) and potassium hydroxide (five granules) were added thereto followed by stirring at 50° C. for 1 day. The residue was neutralized with 2N hydrochloric acid, and extracted with diethyl ether. The organic layer was washed with brine, dried over anhydrous sodium sulfate and the solvent was distilled off under reduced pressure. Thus obtained residue was purified by HPLC to obtain the target compound (3.7 mg).

Provenance & Evidence