HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → HCID 67021935, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 4-[4-Morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]aniline | HCID 67021644 | — |
| Product | HCID 67021935 | HCID 67021935 | 50% |
Reaction Steps
Following the procedure described in example 34, reaction of 4-[4-morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]aniline (22 mg, 0.06 mmol) (22 mg, 0.06 mmol, triphosgene (18 mg, 0.06 mmol) and isopropylamine (11 mg, 0.18 mmol) gave the title compound as off-white solid (13.6 mg, 50% yield). MS (ESI) m/z 454.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039469B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-5429efc8dcd042a8b1cf9f391b5b4ba9 |
| Source note | uspto-grants-2011_10 |