反应详情

温度

90 °C

In a three necked flask under nitrogen equipped was dissolved 2,4-dichloro-6-morpholin-4-yl-[1,3,5]triazine (610 mg, 2.6 mmol), tributyldihydropyranylstannane (1.45 g, 3.89 mmol, 1.5 eq), and (Ph3P)2PdCl2 (150 mg, 0.21 mmol, 0.1 eq) in anhydrous dioxan (5 ml). The reaction mixture was heated under stirring to 90° C. for 16 hrs. For purification silica gel (10 g) was added to the mixture and the solvent was removed to let the product adsorbed on the silica gel. The silica gel plug was placed on a column and the mixture was flash chromatographed with hexane:ethyl acetate (10:1) to give after removal solvent the product as off white solid (345 mg=47% yield); MS (ESI) m/z 281.

1. customIn a three necked flask under nitrogen equipped
2. temperatureThe reaction mixture was heated
3. customFor purification silica gel (10 g)
4. additionwas added to the mixture
5. customthe solvent was removed
6. customchromatographed with hexane:ethyl acetate (10:1)
7. customto give
8. customafter removal solvent the product as off white solid (345 mg=47% yield)