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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1665528Generated: October 29, 2026

Trifluoroacetic acid → HCID 44546614, compound

https://huagongshe.com/reaction/1665528

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantGlycine methyl ester hydrochlorideHCID 122755—
ReactantHCID 44548798HCID 44548798—
CatalystTriethylamineHCID 8471—
ProductHCID 44546614HCID 44546614—

Reaction Steps

Starting from 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(4-oxopiperidin-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea.TFA (50 mg) and glycine methyl ester hydrochloride (20 mg) and triethylamine (10 drops) and following the procedure as outlined in example 118 the title compound was isolated as its di-TFA salt after HPLC purification; MS (ES+) 574.8 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08039469B2
Source datasetuspto-grants-2011_10
ORD IDord-9b98454a9df14326b7fad0da8991daca
Source noteuspto-grants-2011_10