1-Hydroxybenzotriazole → HCID 44230952, compound

Participants

Reaction Conditions

Reaction Steps

HOBt (23 mg, 0.17 mmol) and DIPEA (44.8 mg, 0.35 mmol) were added to a stirred solution of 2,4-dichloro-5-fluorobenzoic acid (29 mg, 0.14 mmol) in DMF (1 mL). The reaction mixture was cooled to 10° C. and EDCI.HCl (33 mg, 0.17 mmol) followed by N-biphenyl-4-yl-3-oxo-3-piperazin-1-yl-propionamide hydrochloride (50 mg, 0.14 mmol) were added. The reaction mixture was stirred at room temperature overnight, then diluted with water. The resulting precipitate was filtered to afford 50 mg (70%) of N-biphenyl-4-yl-3-[4-(2,4-dichloro-5-fluoro-benzoyl)-piperazin-1-yl]-3-oxo-propionamide. LCMS: 514.11 (M+1)+ 100%. 1H NMR: (CDCl3): δ 9.6 (d, 1H), 7.6 (m, 7H), 7.44 (t, 2H), 7.34 (t, 1H), 7.14 (d, 1H), 3.96 (bs, 2H), 3.72 (m, 4H), 3.54 (d, 2H), 3.34 (m, 2H).

Provenance & Evidence