Water → HCID 21856677, compound

Participants

Reaction Steps

Mono ethyl malonyl chloride (375 mg, 2.49 mmol) was added dropwise to a stirred solution of 4-phenyl-thiazol-2-ylamine (400 mg, 2.26 mmol) and DIEA (733 mg, 5.67 mmol) in CHCl3 (4 mL) at 0° C. and the resulting mixture was stirred for 20 minutes at room temperature. The mixture was diluted with water (5 mL) and extracted with chloroform. The organic layer was washed with saturated sodium bicarbonate solution, brine, dried over Na2SO4, and concentrated to afford 302 mg (46%) of N-(4-phenyl-thiazol-2-yl)-malonamic acid ethyl ester.

Provenance & Evidence