HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-[4-(2-Bromo-benzoyl)-piperazin-1-yl]-3-oxo-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-[4-(2-Bromo-benzoyl)-piperazin-1-yl]-3-oxo-propionic acid tert-butyl ester | HCID 57875793 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-[4-(2-Bromo-benzoyl)-piperazin-1-yl]-3-oxo-propionic acid | HCID 57875801 | 87.1% |
Reaction Steps
A solution of 3-[4-(2-bromo-benzoyl)-piperazin-1-yl]-3-oxo-propionic acid tert-butyl ester (400 mg, 0.97 mmol) in dioxane.HCl (4 mL) was stirred at 0° C. for 30 minutes. The reaction mixture was concentrated to afford 300 mg of 3-[4-(2-bromo-benzoyl)-piperazin-1-yl]-3-oxo-propionic acid. LCMS: 356.02 (M+1)+, 96.9%, H1NMR: (DMSO-d6): δ 12.6 (s, 1H), 7.7 (d, 1H), 7.54-7.32 (m, 3H), 3.7-3.4 (m, 8H), 3.2-3.06 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039463B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-787ad03e29a143fcaa28c2f3c91f61ff |
| Source note | uspto-grants-2011_10 |