反应详情

KOH (38 mg, 0.67 mmol) was added to a solution 2-fluoro-malonic acid diethyl ester (100 mg, 0.563 mmol) in methanol (0.7 mL). The reaction mixture was stirred for 4 hours at ambient temperature then concentrated. The residue was diluted with water, acidified with conc. HCl, and the product was extracted with dichloromethane. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford 70 mg (77%) of 2-fluoro-malonic acid monomethyl ester

1. concentrationthen concentrated
2. additionThe residue was diluted with water
3. extractionthe product was extracted with dichloromethane
4. dry with materialThe organic layer was dried over sodium sulfate
5. concentrationconcentrated under reduced pressure