Water → HCID 57875825, compound

Participants

Reaction Steps

LiOH.H2O (25 mg, 0.59 mmol) was added to a solution of N-biphenyl-4-yl-2-fluoro-malonamic acid methyl ester (114 mg, 0.39 mmol) in a mixture of methanol (0.5 mL), THF (1 mL) and H2O (0.3 mL). The resulting mixture was stirred for 2 hours at ambient temperature then concentrated. The resulting residue was diluted with water, acidified with conc. HCl. The resulting precipitate was isolated by filtration and dried to afford 35 mg (32%) of N-biphenyl-4-yl-2-fluoro-malonamic acid

Provenance & Evidence