Pyridine → 4'-Bromoacetanilide

Participants

Reaction Steps

Pyridine (551 mg, 5.8 mmol) and acetic anhydride (650 mg, 0.6 mL, 6.4 mmol) were added to a cold solution (at 0° C.) of 4-bromo-phenylamine (1 g, 5.8 mmol) in DCM (10 mL) and stirring was continued at ambient temperature for 2 hrs. The reaction mixture was diluted with DCM and washed the organic layer with water followed by brine solution. The organic layer collected was dried over sodium sulfate and concentrated under reduced pressure to afford 900 mg (69.5% yield) of N-(4-bromo-phenyl)-acetamide.

Provenance & Evidence