反应详情

A mixture of N-(4-thiophen-3-yl-phenyl)-acetamide (90 mg, 0.41 mmol), NaOH (133 mg, 3.3 mmol), MeOH (2 mL) and water (7 mL) was heated to reflux for 12 hr. After completion of the reaction, the reaction mixture was diluted with water, extracted with ethyl acetate, washed with brine solution and dried over sodium sulphate. The organic layer collected was concentrated under reduced pressure to afford 83 mg (crude) of 4-thiophen-3-yl-phenylamine.

1. temperaturewas heated
2. temperatureto reflux for 12 hr
3. customAfter completion of the reaction
4. extractionextracted with ethyl acetate
5. washwashed with brine solution
6. dry with materialdried over sodium sulphate
7. customThe organic layer collected
8. concentrationwas concentrated under reduced pressure