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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1665796Generated: October 30, 2026

Hydrochloric Acid → 5-Acetyl-1H-indole-2-carboxylic acid

https://huagongshe.com/reaction/1665796

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantPotassium HydroxideHCID 14797—
ReactantHCID 4162576HCID 4162576—
ReactantHCID 11770291HCID 11770291—
SolventEthanolHCID 702—
Product5-Acetyl-1H-indole-2-carboxylic acidHCID 13705809—
Product3-Acetyl-1H-indole-2-carboxylic acidHCID 15090443—

Reaction Steps

Saponification of 2b and 3b with 10% KOH in ethanol at 60° C. for 1 h followed by acidification with 1M HCl provided 3-acetyl-1H-indole-2-carboxylic acid 4b and 5-acetyl-1H-indole-2-carboxylic acid 5b in 95% and 93% yield respectively. The crude acids were used directly without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08039623B2
Source datasetuspto-grants-2011_10
ORD IDord-810ac86246c9425ebff1b029c8ab0c95
Source noteuspto-grants-2011_10