Lansoprazole → Lansoprazole sulfide

HRID 1665820Notes

Reaction equation

HRID 1665820 reaction equation
[CH3:1][C:2]1[C:3]([O:20][CH2:21][C:22]([F:25])([F:24])[F:23])=[CH:4][CH:5]=[N:6][C:7]=1[CH2:8][S+:9]([O-])[C:10]1[NH:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=2[N:18]=1>C(O)C>[CH3:1][C:2]1[C:7]([CH2:8][S:9][C:10]2[NH:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[N:18]=2)=[N:6][CH:5]=[CH:4][C:3]=1[O:20][CH2:21][C:22]([F:23])([F:25])[F:24]

Participants

3

Reactant 1

HCID 3883Lansoprazole2×

Product 1

HCID 1094080Lansoprazole sulfide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The present invention relates to a process for preparing the Crystalline Form A of Lansoprazole, which comprises dissolving Lansoprazole obtained by oxidation of 2-([3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]-methyl)thio-1H-benzimidazole in ethanol, adding water thereto, stirring the mixture at the temperature range of from 15 to 40° C. for 0.5 to 4 hours, and filtering and drying the resulting product.

Sources & evidence

ORD record
ord-0cf1d241438f4ca2b2487c3dc2720d79
Source dataset
uspto-grants-2011_10
Patent number
US08039631B2

Reaction notes

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