3-(2-Ethyl-4-hydroxymethyl-6-methyl-phenyl)propionic acid → 3-(2-Ethyl-4-formyl-6-methylphenyl)propionic acid

Participants

Reaction Conditions

Reaction Steps

A solution of 3-(2-ethyl-4-hydroxymethyl-6-methyl-phenyl)-propionic acid (2.8 g, 12.6 mmol) in acetic acid (50 mL) is treated with MnO2 (3.9 g, 45.4 mmol) and the resulting mixture is stirred at 80° C. for 4 h. The mixture is filtered and the filtrate is concentrated. The crude product is purified by CC on silica gel eluting with DCM to give 3-(2-ethyl-4-formyl-6-methyl-phenyl)-propionic acid (1.76 g) as a beige solid; LC-MS: tR=0.86 min.

Provenance & Evidence