Methanesulfonyl chloride → HCID 57508924, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydro-benzo[c]thiophen-1-yl)-3-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-propan-1-one (255 mg, 0.615 mmol) in THF (10 mL) and DIPEA (0.29 mL, 1.70 mmol) is added methane sulfonylchloride (0.09 mL, 1.15 mmol) at 0° C. The reaction mixture is stirred at 0° C. for 30 min. The reaction mixture is diluted with diethyl ether, washed with sat. aq. NaHCO3 solution followed by 10% aq. citric acid solution, dried over Na2SO4 and evaporated to give methanesulfonic acid 2-{4-[3-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydro-benzo[c]thiophen-1-yl)-3-oxo-propyl]-2,6-dimethyl-phenoxy}-ethyl ester (300 mg) as a brown resin; LC-MS: tR=1.18 min, [M+1]+=493.36.

Provenance & Evidence