Hydrochloric Acid → Isoquinoline, 6-hydroxy-1,2,3,4-tetrahydro-, hydrochloride

HRID 1665985Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1665985
[ClH:1].[OH:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[CH2:6][CH2:7][NH2:8].Cl.[CH3:13]O>C=O>[ClH:1].[CH2:13]1[C:9]2[C:5](=[CH:4][C:3]([OH:2])=[CH:11][CH:10]=2)[CH2:6][CH2:7][NH:8]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 770013-(2-Aminoethyl)phenol hydrochloride

Produkt 1

HCID 2752309Isoquinoline, 6-hydroxy-1,2,3,4-tetrahydro-, hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 712FormaldehydeLösungsmittel

Reaktionsbedingungen

Temperatur
45 °C

Versuchsvorschrift

To a solution of 3-hydroxyphenethylamine hydrochloride (3.0 g) in methanol (6 mL), formaldehyde (37% aqueous solution, 2.7 mL) and a catalytic amount of concentrated hydrochloric acid were added, followed by stirring at 45° C. for 18 hours. The reaction mixture was concentrated and the obtained solid was washed with a mixed solvent of diisopropyl ether-methanol (1:2) to thereby give the title compound (2.8 g) having the following physical properties.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. washthe obtained solid was washed with a mixed solvent of diisopropyl ether-methanol (1:2)

Quellen und Nachweise

ORD-Eintrag
ord-a1a2dd69e7f24574a455943c9c51ee2a
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08039674B2

Notizen zur Reaktion

Wird geladen…