HCID 67358805, compound → HCID 67357591, compound

HRID 1666012Notes

Reaction equation

HRID 1666012 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:12][N:11]([C:13]3[CH:18]=[CH:17][CH2:16][NH:15][N:14]=3)[CH2:10][C@H:9]2[C:19]([O:21]C)=[O:20])=[CH:4][CH:3]=1.ClC1C=CC([C@@H]2CN(C3C=CCNN=3)C[C@H]2C([O-])=O)=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:12][N:11]([C:13]3[CH:18]=[CH:17][CH2:16][NH:15][N:14]=3)[CH2:10][C@H:9]2[C:19]([OH:21])=[O:20])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 67358805HCID 67358805, compoundHCID 86641586HCID 86641586, compound

Product 1

HCID 67357591HCID 67357591, compoundYield 70%

Procedure

The title compound (0.48 g, 70%) was prepared from the product of Step A, (3S,4R)-4-(4-chlorophenyl)-1-(1,6-dihydropyridazin-3-yl)pyrrolidine-3-carboxylate (0.72 g, 2.27 mmol) according to the same procedure as in Step C of Preparation 17.

Workup

  1. customaccording to the same procedure as in Step C of Preparation 17

Sources & evidence

ORD record
ord-963d137076df439a8e1c75cf5eecf560
Source dataset
uspto-grants-2011_10
Patent number
US08039622B2

Reaction notes

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