HCID 67357512, compound → HCID 67358412, compound

HRID 1666013Notes

Reaction equation

HRID 1666013 reaction equation
ClC1C=CC([C@@H]2CN(C3N=NC(Cl)=CC=3)C[C@H]2C(OC)=O)=CC=1.[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([C@@H:31]2[CH2:35][N:34]([C:36]3[CH:41]=[CH:40][C:39](=[O:42])[NH:38][N:37]=3)[CH2:33][C@H:32]2[C:43]([O:45]C)=[O:44])=[CH:27][CH:26]=1>>[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([C@@H:31]2[CH2:35][N:34]([C:36]3[CH:41]=[CH:40][C:39](=[O:42])[NH:38][N:37]=3)[CH2:33][C@H:32]2[C:43]([OH:45])=[O:44])=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 67357512HCID 67357512, compoundHCID 86641587HCID 86641587, compound

Product 1

HCID 67358412HCID 67358412, compoundYield 70%

Procedure

The title compound (0.51 g, 70%) was prepared from the product of Step A, methyl (3S,4R)-4-(4-chlorophenyl)-1-(6-oxo-1,6-dihydropyridazin-3-yl)pyrrolidine-3-carboxylate (0.76 g, 2.28 mmol) according to the same procedure as in Step C of Preparation 17.

Workup

  1. customaccording to the same procedure as in Step C of Preparation 17

Sources & evidence

ORD record
ord-2ae02a42356f4591825969707f57f9c4
Source dataset
uspto-grants-2011_10
Patent number
US08039622B2

Reaction notes

Loading…