HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4,6-Dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4,6-Dichloro-2-(methylthio)-5-pyrimidinecarbaldehyde oxime | HCID 21822251 | — |
| Product | 4,6-Dichloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile | HCID 4201620 | — |
Reaction Steps
4,6-Dichloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde oxime (7.20 g, 30.38 mmol) was added to neat thionyl chloride (29.63 g, 245 mmol), then the mixture was heated to reflux for 4 hours. The reaction mixture was poured onto ice-water. The precipitate of 4,6-dichloro-2-methylsulfanyl-pyrimidine-5-carbonitrile was collected and dried (Yield=6.15 g, 92%). 1H-NMR (300 MHz, CDCl3): δ 2.75 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044040B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-c8d00a9692284297bc63e6ee3f370e86 |
| Source note | uspto-grants-2011_10 |