HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1666070Generated: October 30, 2026
Diisopropylethylamine → 3-{5-Cyano-6-[(2,2-dimethyl-propyl)-methyl-amino]-3-fluoro-pyridin-2-ylamino}-N-methoxy-4-methyl-benzamide
https://huagongshe.com/reaction/1666070
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | (2,2-Dimethylpropyl)(methyl)amine | HCID 12910381 | — |
| Reactant | 3-(6-chloro-5-cyano-3-fluoro-pyridin-2-ylamino)-N-methoxy-4-methyl-benzamide | HCID 86588800 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-{5-Cyano-6-[(2,2-dimethyl-propyl)-methyl-amino]-3-fluoro-pyridin-2-ylamino}-N-methoxy-4-methyl-benzamide | HCID 10179043 | 5.9% |
Reaction Steps
A mixture of 3-(6-chloro-5-cyano-3-fluoro-pyridin-2-ylamino)-N-methoxy-4-methyl-benzamide (55.6 mg, 0.166 mmol), N-methyl-neopentylamine (70 mg, 0.511 mmol), diisopropylethylamine (0.1 mL) and potassium fluoride (12 mg) in DMSO (1 mL) was heated to 150° C. overnight. The product (3.9 mg, 5.9%) was isolated after purification by HPLC. C21H26FN5O2 MS m/e=400 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08044040B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-531c1b504e9c4e139f9389420ed6e035 |
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| Source note | uspto-grants-2011_10 |
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