Dimethyl Sulfoxide → HCID 67445301, compound

Participants

Reaction Conditions

Reaction Steps

To a portion of 576 mg of 1-methylpiperidine-4-ol (576 mg; 5 mmol) is added 616 mg of potassium tert.-butoxide (5.5 mmol) followed by 4.0 mL of DMSO. After stirring this mixture at r.t. for 1 h a portion of 1.0 mL of this mixture is added at r.t. to 19 mg of 3-{5-cyano-6-[(2,2-dimethyl-propyl)-methyl-amino]-2-methanesulfonyl-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide (0.043 mmol) on 0.2 mL of DMSO. The mixture was heated at 60° C. for 3 h. At r.t. 5 mL of ethyl acetate is added and the organic layer is washed with brine (1×4 mL). The organic layer is dried (MgSO4), volatiles are removed in vacuo and the product is purified via reversed phase prep. HPLC. (Yield: 18.6 mg; 0.026 mmol; 56%). MS (m/z): 480 (M+H).

Provenance & Evidence