HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1666089Generated: October 29, 2026
Diisopropylethylamine → 3-(R)-[4-[(2,2-Dimethyl-propyl)-methyl-amino]-6-(2-methyl-5-methylcarbamoyl-phenylamino)-pyrimidin-2-ylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/1666089
Participants
| Role | Name | HCID | Charge |
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| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (2,2-Dimethylpropyl)(methyl)amine hydrochloride | HCID 22393520 | — |
| Reactant | 3-(R)-[4-fluoro-6-(2-methyl-5-methylcarbamoyl-phenylamino)-pyrimidin-2-ylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 58928515 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-(R)-[4-[(2,2-Dimethyl-propyl)-methyl-amino]-6-(2-methyl-5-methylcarbamoyl-phenylamino)-pyrimidin-2-ylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 58928534 | — |
Reaction Steps
A mixture of 3-(R)-[4-fluoro-6-(2-methyl-5-methylcarbamoyl-phenylamino)-pyrimidin-2-ylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester (0.36 g, 0.81 mmol), N-methyl-neopentylamine hydrochloride (411 mg, 3 mmol) and DIEA (0.4 mL) in 1,4-dioxane (0.5 mL) was stirred at 90° C. overnight. After removing the solvent under reduced pressure the desired product (81 mg) was purified by silica gel chromatography. C28H43N7O3 MS m/e=526 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08044040B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-5094cdd06b574030aebbe19ed8ff304c |
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| Source note | uspto-grants-2011_10 |
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